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Research and Clinical Studies

To support the growing body of research studying the efficacy of cognitive training, HappyNeuron Pro’s scientific team partners with research institutions worldwide to explore how HappyNeuron Pro helps with various conditions.

Below is a continually updated list of completed and ongoing studies using HappyNeuron Pro.

This page is for information only. Our goal is to help the entire digital therapeutic industry continue the research into the best way to care for individuals’ cognition. HappyNeuron does not yet sell any products or treatment tools that are FDA approved. If you are interested in using HappyNeuron in your research, please see our research offer.

Search (Topic, Authors, Institutions, etc.):
Status:
2015
2016
«Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability
Completed
Intellectual disability
Children
+
Institutions:
France
Centre Hospitalier le Vinatier, Center of Cognitive Neuroscience, CNRS, University Lyon 1
Investigators:
Caroline Demily, Caroline Rigard, Élodie Peyroux, Gabrielle Chesnoy-Servanin, Aurore Morel, Nicolas Franck
Size:
30 Participants
Publication:
Demily, Caroline & Rigard, Caroline & Peyroux, Élodie & Chesnoy-Servanin, Gabrielle & Morel, Aurore & Franck, Nicolas. (2016). «Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability. Frontiers in psychiatry. 7. 10. 10.3389/fpsyt.2016.00010.
–
2014
Increased activation in Broca’s area after cognitive remediation in schizophrenia
Completed
Schizophrenia
fMRI
+
Institutions:
Switzerland
Lausanne Hospital
Investigators:
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey
Size:
16 Participants
Publication:
Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca’s area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209.
–
2011
2013
Cognitive Remediation for Treatment Resistant Depression
Completed
Depression
+
Institutions:
Canada
Queen’s University, Kingston, ON
Investigators:
Christopher Bowie
Publication:
Bowie CR, Gupta M, Holshausen K, Jokic R, Best M, Milev R. Cognitive remediation for treatment-resistant depression: effects on cognition and functioning and the role of online homework. J Nerv Ment Dis. 2013;201(8):680‐685. doi:10.1097/NMD.0b013e31829c5030
–
2008
2011
Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial
Completed
Schizophrenia
+
Institutions:
France
Le Vinatier Hospital – Bron, Cognitive Neuroscience Centre – Lyon, Sainte-Anne Hospital – Paris
Investigators:
Nicolas Franck
Size:
280 Participants
Publication:
Franck N, Duboc C, Sundby C, et al. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophr Res. 2013;147(1):68‐74. doi:10.1016/j.schres.2013.03.009
–
2004
2006
MNESIS Project – Using the internet as a means of social integration and cognitive stimulation in a residential unit for elderlies
Completed
Geriatrics
+
Institutions:
France
Lyon 2 University, Lyon INSA (ICTT), Medica-France
Investigators:
Bobillier Chaumon, Marc-Eric & Michel, Christine & Tarpin-Bernard, Franck & Croisile, Bernard
Publication:
Bobillier Chaumon, Marc-Eric & Michel, Christine & Tarpin-Bernard, Franck & Croisile, Bernard. (2014). Can ICT improve the quality of life of elderly adults living in residential home care units (RHCU)? From actual impacts to hidden artifacts. Behaviour and Information Technology. 33. 10.1080/0144929X.2013.832382.
–
2020
2021
Promoting cognitive health in schizophrenia during and after the COVID-19 pandemic: A national collaborative effort to implement online psychological interventions.
In Progress
Schizophrenia
+
Institutions:
Canada
Douglas Institute in Montréal, Royal’s Institute of Mental Health Research in Ottawa, Kingston Health Sciences Centre, Ontario Shores Centre for Mental Health Sciences in Toronto, Vancouver Coastal Health/UBC
Investigators:
Martin Lepage, Synthia Guimond, Michael Bodnar, Christopher Bowie, Michael Best, Todd Woodward, Mahesh Menon
Size:
100 Participants
–
2020
2024
Efficacy of Personalizing Cognitive Remediation for Schizophrenia by Targeting Impairments in Early Auditory Processing
In Progress
Schizophrenia
+
Institutions:
USA
Columbia University, NIMH
Investigators:
Alice Medalia, Alice Saperstein, Daniel Javitt, Min Qian
Size:
200 Participants
Trial Registration:
See Registration
–
2020
2021
A Measure of the Efficacy of Cognitive Remediation Therapy in an Inpatient Setting
In Progress
Schizophrenia
Bipolar
+
Institutions:
Canada
Saskatchewan Health Authority
Investigators:
Brent Nixon, Anne Pleydon, Christine Tait, Kingsley Nwachukwu, Fiyinfoluwa Peluola, Mansfield Mela
Size:
48 Participants
–
2020
Comparison of a standard computer‐assisted cognitive training program to a music enhanced program: A mixed methods study
Completed
Cancer
Music
+
Institutions:
USA
Texas Woman’s University
Investigators:
Theresa M. Smith, Wanyi Wang
Size:
25 Participants
Publication:
Smith, TM, Wang, W. Comparison of a standard computer‐assisted cognitive training program to a music enhanced program: A mixed methods study. Cancer Reports. 2020;e1325. https://doi.org/10.1002/cnr2.1325
–
2020
2022
Cognitive Remediation in Forensic Mental Health Care
In Progress
Forensics
Mental Heath
+
Institutions:
Canada
The Royal Ottawa Mental Health Centre
Investigators:
Patrizia Pezzoli, Michael Seto, Synthia Guimond, Sanjiv Gulati
Size:
30 Participants
Trial Registration:
See Registration
Presentation:
Abstract at the Cognitive Remediation Conference 2022
–
2019
2021
Activation therapy for the treatment of inpatients with depression – protocol for a randomised control trial compared to treatment as usual
In Progress
Depression
+
Institutions:
New Zealand
University of Otago, Christchurch
Investigators:
Ian RE Averill, Ben Beaglehole, Katie M. Douglas, Jennifer Jordan, Marie T. Crowe, Maree Inder,Cameron J. Lacey, Christopher M. Frampton, Christopher R. Bowie and Richard J. Porter
Size:
170 Participants
Presentation:
Averill, I.R.E., Beaglehole, B., Douglas, K.M. et al. Activation therapy for the treatment of inpatients with depression – protocol for a randomised control trial compared to treatment as usual. BMC Psychiatry 19, 52 (2019). https://doi.org/10.1186/s12888-019-2038-2
–
2019
Is social cognitive training efficient in autism? A pilot single-case study using the RC2S+ program
Completed
Social Cognition
Autism
+
Institutions:
France
Le Vinatier hospital, Université de Lyon, Institut des Sciences Cognitives, Lyon
Investigators:
Elodie Peyroux, Nicolas Franck
Size:
1 Participants
Publication:
Peyroux E, Franck N. Is social cognitive training efficient in autism? A pilot single-case study using the RC2S+ program. Neurocase. 2019;25(6):217‐224. doi:10.1080/13554794.2019.1666877
–
2019
2021
Improving Mental Functioning in Patients With Schizophrenia with a Drug and a Computerized Cognitive Training
In Progress
Schizophrenia
Drug
+
Institutions:
World
Boehringer Ingelheim
Investigators:
40 Sites in 6 countries
Size:
200 Participants
Trial Registration:
See Registration
–
2019
2021
Improving Cognitive Skills for People with Mental Illness to Increase Vocational and Psychosocial Outcomes: The Employ Your Mind Program
Completed
Severe Mental Illness
Employment
+
Institutions:
Autralia
St Vincent’s Hospital, Melbourne
Investigators:
Anne Miles, Caroline Crosse, Zoe Jenkins, Paul Morgan, Ellie Fossey, Carol Harvey, David Castle
Size:
32 Participants
Publication:
Miles, A., Crosse, C., Jenkins, Z. et al. Improving Cognitive Skills for People with Mental Illness to Increase Vocational and Psychosocial Outcomes: The Employ Your Mind Program. J. Psychosoc. Rehabil. Ment. Health (2021). https://doi.org/10.1007/s40737-021-00225-9
–
2019
2021
Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a
Completed
Multiple Sclerosis
+
Institutions:
Israel
Sheba Medical Center, Ramat Gan
Investigators:
Shay Menascu, Roy Aloni, Mark Dolev, David Magalashvili, Keren Gutman, Sapir Dreyer‑Alster, Franck Tarpin‑Bernard, Ran Achiron, Gil Harari and Anat Achiron
Size:
100 Participants
Publication:
Menascu, S., Aloni, R., Dolev, M. et al. Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a. J NeuroEngineering Rehabil 18, 175 (2021). https://doi.org/10.1186/s12984-021-00968-3
–
2019
2021
A randomised controlled trial of psychotherapy and cognitive remediation to target cognition in mood disorders
Completed
Bipolar
Mood
+
Institutions:
New Zealand
University of Otago, Christchurch
Investigators:
Katie M. Douglas,Samantha Groves,Marie T. Crowe,Maree L. Inder,Jennifer Jordan,Dave Carlyle,Hayley Wells,Ben Beaglehole,Roger Mulder,Cameron Lacey,Suzanne E. Luty,Kate Eggleston,Christopher M. A. Frampton,Christopher R. Bowie,Richard J. Porter
Size:
68 Participants
Publication:
Douglas, KM, Groves, S, Crowe, MT, et al. A randomised controlled trial of psychotherapy and cognitive remediation to target cognition in mood disorders. Acta Psychiatr Scand. 2022; 145: 278– 292. doi:10.1111/acps.13387
–
2018
2019
An Evaluation of the Effectiveness and Feasibility of a Cognitive Remediation Program in a Residential Substance Use Treatment Facility
In Progress
Addiction
+
Institutions:
Australia
Wattlegrove Rehab Program, University of Queensland, Lives lived well
Investigators:
Leanne Hides, Julaine Allan, Anna Thompson, Frances Dark
Size:
65 Participants
Presentation:
Poster presented in Nov 2019 at the Australasian Professional Society for Alcohol and other Drugs
Publication:
Pending
–
2018
2022
Training-induced plasticity of multitasking in everyday-like motor behavior
In Progress
Multitasking
Geriatrics
+
Institutions:
Germany
Technical University of Chemnitz, University of Münster
Investigators:
Claudia Voelcker-Rehage, Otmar Bock, Melanie Mack
Size:
150 Participants
Trial Registration:
See Registration
Presentation:
Presentation
–
2018
2021
Examine the effects of prolonged cognitive remediation on sustaining cognitive gains and functional recovery in schizophrenia.
In Progress
Schizophrenia
+
Institutions:
Singapore
Institute of Mental Health, Singapore Institute of Technology
Investigators:
Ho New Fei, Sim Kang Jimmy, Chee Keong Lee, Chen Guoyang, Wang Mingyuan, Suhailah Bte Abd Shukor, Daniel Poremski
Size:
45 Participants
–
2018
2019
Neuropsychological management of multiple sclerosis: evaluation of a supervised and customized cognitive rehabilitation program for self-used at home (SEPIA): protocol for a randomized controlled trial
Completed
Multiple Sclerosis
+
Institutions:
France
Centre Hospitalier Universitaire de Caen Normandie
Investigators:
Caroline Harand, France Daniel, Audrey Mondou, Damien Chevanne, Christian Creveuil, Gilles Defer
Size:
40 Participants
Trial Registration:
See Registration
Publication:
Harand, C., Daniel, F., Mondou, A. et al. Neuropsychological management of multiple sclerosis: evaluation of a supervised and customized cognitive rehabilitation program for self-used at home (SEPIA): protocol for a randomized controlled trial. Trials 20, 614 (2019). https://doi.org/10.1186/s13063-019-3715-7
–
2017
2018
Experiences With a Cognitive Rehabilitation Program for Five Female Breast Cancer Survivors: A Focus Group Study
Completed
Cancer
Focus Group
+
Institutions:
USA
Texas Woman’s University, University of Texas
Investigators:
Theresa M. Smith, Karen Ratcliff, Rachel A. Perry
Size:
5 Participants
Publication:
Theresa M. Smith, Karen Ratcliff, Rachel A. Perry. Experiences With a Cognitive Rehabilitation Program for Five Female Breast Cancer Survivors: A Focus Group Study. Annals of International Occupational Therapy. 2019;2(4):152-159https://doi.org/10.3928/24761222-20190625-03
–
2017
2019
Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.
Completed
Bipolar
+
Institutions:
Denmark
Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet
Investigators:
Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW
Size:
58 Participants
Trial Registration:
See Registration
Publication:
Ott CV, Vinberg M, Bowie CR, et al. Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial [published correction appears in Trials. 2019 Apr 8;20(1):201]. Trials. 2018;19(1):487. Published 2018 Sep 12. doi:10.1186/s13063-018-2860-8
–
2017
2018
The effects of computer based cognitive rehabilitation in patients with symptoms of visuospatial neglect or hemianopsia after stroke.
Completed
Stroke
+
Institutions:
Denmark
Bispebjerg Hospital, Department of Neurology, Copenhagen
Investigators:
Svaerke K, Omkvist K, Havsteen I, Christensen H
Size:
14 Participants
Publication:
Svaerke KW, Omkvist KV, Havsteen IB, Christensen HK. Computer-Based Cognitive Rehabilitation in Patients with Visuospatial Neglect or Homonymous Hemianopia after Stroke. J Stroke Cerebrovasc Dis. 2019;28(11):104356. doi:10.1016/j.jstrokecerebrovasdis.2019.104356
–
2017
2021
Restoration of Cognitive Function With TDCS and Training in Schizophrenia
In Progress
Schizophrenia
tDCS
+
Institutions:
USA
Department of Veterans Affairs Office of Research and Development, Minneapolis VA Health Care System, Minneapolis
Investigators:
Tasha Marie Nienow
Size:
110 Participants
Trial Registration:
See Registration
–
2017
2018
A Comparison of two Computer-Assisted Cognitive Training Program Outcomes for Breast Cancer Survivors: A Pilot Study
Completed
Cancer
+
Institutions:
USA
Department of Occupational Therapy and Rehabilitation Sciences, The University of Texas Medical Branch
Investigators:
Theresa Smith, Karen Ratcliff
Size:
20 Participants
Publication:
Theresa M. Smith, Karen Ratcliff, A Comparison of two Computer-Assisted Cognitive Training Program Outcomes for Breast Cancer Survivors: A Pilot Study. Journal of Korean Society of Occupational Therapy 2019;27(3):145-156
–
2016
2018
Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed
Completed
Depression
+
Institutions:
New Zealand
University of Otago, Christchurch
Investigators:
Ian RE Averill, Marie Crowe, Chris M Frampton, Ben Beaglehole, Cameron J Lacey, Jennifer Jordan, Lynere D Wilson, Katie M Douglas and Richard J Porter
Size:
24 Participants
Publication:
Averill, I. R., Crowe, M., Frampton, C. M., Beaglehole, B., Lacey, C. J., Jordan, J., … Porter, R. J. (2018). Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed. Australian & New Zealand Journal of Psychiatry, 52(7), 652–659. https://doi.org/10.1177/0004867417753549
–
2016
2018
An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders.
Completed
Schizophrenia
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and Department of Psychology, Queen’s University, Kingston ON
Investigators:
Best MW, Milanovic M, Shamblaw AL, Muere A, Lambe LJ. Hong IK, Haque MK, Bowie CR.
Size:
70 Participants
Publication:
Best MW, Milanovic M, Shamblaw AL, et al. An examination of the moderating effects of neurophysiology on treatment outcomes from cognitive training in schizophrenia-spectrum disorders [published online ahead of print, 2019 Feb 15]. Int J Psychophysiol. 2019;S0167-8760(18)30863-8. doi:10.1016/j.ijpsycho.2019.02.004
–
2016
2018
A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning.
Completed
Schizophrenia
+
Institutions:
Canada
Department of Psychology and Department of Psychiatry, Queen’s University, Kingston, ON
Investigators:
Best MW, Milanovic M, Iftene F, Bowie CR
Size:
70 Participants
Trial Registration:
See Registration
Publication:
Best MW, Milanovic M, Iftene F, Bowie CR. A Randomized Controlled Trial of Executive Functioning Training Compared With Perceptual Training for Schizophrenia Spectrum Disorders: Effects on Neurophysiology, Neurocognition, and Functioning. Am J Psychiatry. 2019;176(4):297‐306. doi:10.1176/appi.ajp.2018.18070849
–
2016
2017
Effects of simultaneous aerobic and cognitive training on executive functions, cardiovascular fitness and functional abilities in older adults with mild cognitive impairment
Completed
MCI
Physical Activity
+
Institutions:
France
University Paris Sud, Institut Universitaire de Gériatrie de Montréal, University Hospital of Amiens-Picardie, University of Poitiers
Investigators:
Laure Combourieu Donnezan, Alexandra Perrot, Sylvie Belleville, Frédéric Bloch, Gilles Kemoun
Size:
69 Participants
Publication:
Combourieu Donnezan, L., Perrot, A., Belleville, S., Bloch, Fréé., Kemoun, G., Effects of simultaneous aerobic and cognitive training on executive functions, cardiovascular fitness and functional abilities in older adults with mild cognitive impairment, Mental Health and Physical Activity (2018), doi: 10.1016/j.mhpa.2018.06.001.
–
2016
2017
Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial
Completed
SMI
Employment
+
Institutions:
Australia
University of Sydney, Macquarie University
Investigators:
Anthony WF Harris, Tanya Kosic, Jean Xu, Chris Walker, William Gye, Antoinette Redoblado Hodge
Size:
86 Participants
Trial Registration:
See Registration
Publication:
Harris AW, Kosic T, Xu J, Walker C, Gye W, Redoblado Hodge A. Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial. JMIR Ment Health. 2017;4(3):e30. Published 2017 Sep 20. doi:10.2196/mental.6982
–
2016
2018
Helping people with a mental illness obtain work: the Health Optimisation Program for Employment
Completed
Mental Illness
Employment
+
Institutions:
Australia
St Vincent’s Hospital, Melbourne
Investigators:
David Castle, Andrea Phillipou, Gaye Moore, Caroline Crosse AM, Anne Miles
Size:
100 Participants
Publication:
Castle D, Crosse C, Morgain D, et al. Helping people with a mental illness obtain work: the Health Optimisation Program for Employment. Australas Psychiatry. 2016;24(4):337‐341. doi:10.1177/1039856216654400
–
2016
2018
The role of cognitive rehabilitation in patients with type 1 diabetes
Completed
Diabetes
+
Institutions:
Russia
Siberian State Medical University Tomsk, Russian Ministry of Health
Investigators:
YG Samoilova, MV Matveeva, NG Zhukov
Size:
200 Participants
Publication:
Matveeva MV, Samoilova YG, Zhukova NG, Ratkina KR, Yakimovich IY. Raznye vidy reabilitatsii kognitivnoĭ disfunktsii u patsientov s sakharnym diabetom 2-go tipa [Different types of cognitive rehabilitation in patients with type 2 diabetes]. Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(8):12‐17. doi:10.17116/jnevro201911908112
–
2016
2019
Randomized controlled trial of the GT1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia
Completed
Drug
Schizophrenia
+
Institutions:
USA
Yale University
Investigators:
John H. Krystal
Size:
80 Participants
Trial Registration:
See Registration
Publication:
Toral S. Surti, Mohini Ranganathan, Jason K. Johannesen, Ralitza Gueorguieva, Emma Deaso, Joshua G. Kenney, John H. Krystal, Deepak Cyril D’Souza. Randomized controlled trial of the glycine transporter 1 inhibitor PF-03463275 to enhance cognitive training and neuroplasticity in schizophrenia. Schizophrenia Research, Volume 256, 2023, Pages 36-43
–
2016
2019
A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington’s disease (CogTrainHD)
Completed
Huntington’s disease
+
Institutions:
UK
Cardiff University in the Cardiff Huntington’s Disease Research Centre
Investigators:
Emma Yhnell, Hannah Furby, Rachel S. Lowe, Lucy C. Brookes-Howell, Cheney J. G. Drew, Rebecca Playle, Gareth Watson, Claudia Metzler-Baddeley, Anne E. Rosser & Monica E. Busse
Size:
30 Participants
Trial Registration:
See Registration
Publication:
Yhnell, E., Furby, H., Lowe, R.S. et al. A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington’s disease (CogTrainHD). Pilot Feasibility Stud 6, 88 (2020). https://doi.org/10.1186/s40814-020-00623-z
–
2016
2017
Evaluation of cognitive tele-rehabilitation program for children with Attention Deficit Hyperactivity Disorder
Completed
ADHD
Children
+
Institutions:
Spain
Bio functional Studies Institute – Universidad Complutense (Madrid)
Investigators:
Elimelech Duarte, Jesus Alvarado, Alejandra Koeneke
Size:
100 Participants
Publication:
No Publication
–
2015
2022
Prevention of Alzheimer’s Disease With CR Plus tDCS in Mild Cognitive Impairment and Depression
In Progress
Alzheimer’s Disease
tDCS
MCI
+
Institutions:
Canada
Centre for Addiction and Mental Health, Queen’s University, Baycrest Centre for Geriatric Care
Investigators:
Benoit Mulsant
Size:
500 Participants
Trial Registration:
See Registration
–
2015
2017
Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning.
Completed
SMI
EEG
Executive Functionning
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and University of Toronto Department of Psychiatry
Investigators:
Best MW, Gale D, Tran T, Haque MK, Bowie CR
Size:
25 Participants
Publication:
Best MW, Gale D, Tran T, Haque MK, Bowie CR. Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning. Schizophr Res. 2019;203:32‐40. doi:10.1016/j.schres.2017.08.052
–
2015
2018
A comparison of compensatory and restorative cognitive interventions in early psychosis.
Completed
Psychosis
+
Institutions:
Canada
Toronto Centre for Addiction and Mental Health, and University of Toronto Department of Psychiatry
Investigators:
Kidd SA, Herman Y, Virdee G, Bowie CR, Velligan D, Plagiannakos C, Voineskos A.
Size:
56 Participants
Trial Registration:
See Registration
Publication:
Kidd SA, Herman Y, Virdee G, et al. A comparison of compensatory and restorative cognitive interventions in early psychosis. Schizophr Res Cogn. 2019;19:100157. Published 2019 Jul 24. doi:10.1016/j.scog.2019.100157
–
2015
2018
Evaluation of Dallas Metrocare’s Enhanced Program for Early Psychosis (ePEP)
Completed
Psychosis
+
Institutions:
USA
UT Southwestern Medical Center
Investigators:
Carol North, Ana Stan, Debra Bushong, Draper Bushanan
Size:
90 Participants
Presentation:
Presentation
–
2015
2020
The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial
Completed
Psychosis
+
Institutions:
Denmark
Psychiatric Center Copenhagen
Investigators:
Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft
Size:
126 Participants
Trial Registration:
See Registration
Publication:
Glenthøj LB, Fagerlund B, Randers L, et al. The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial. Trials. 2015;16:25. Published 2015 Jan 27. doi:10.1186/s13063-014-0542-8
–
2014
2017
Motivation and engagement during cognitive training for schizophrenia spectrum disorders
Completed
Schizophrenia
+
Institutions:
Canada
Department of Psychology, Queen’s University, Kingston, ON
Investigators:
Michael W.Best, Melissa Milanovic, Tanya Tran, Pauline Leung, Robyn Jackowich, Stéphanie Gauvin, Talia Leibovitz, Christopher R.Bowie
Size:
38 Participants
Publication:
Best MW, Milanovic M, Tran T, et al. Motivation and engagement during cognitive training for schizophrenia spectrum disorders. Schizophr Res Cogn. 2019;19:100151. Published 2019 May 23. doi:10.1016/j.scog.2019.100151
–
2014
2019
Manualized group cognitive-behavioral therapy for social anxiety in first episode psychosis: A randomized controlled trial
In Progress
Psychosis
+
Institutions:
Canada
Douglas Mental Health University Insitute, Montreal, QC & Department of Psychiatry, McGill University, Montréal QC
Investigators:
Martin Lepage, Ashol K. Malla, Philippe-Olivier Harvey, Christopher Bowie
Size:
120 Participants
Trial Registration:
See Registration
–
2014
2019
Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia
In Progress
Schizophrenia
+
Institutions:
Canada
University of British Columbia
Investigators:
Todd Woodward
Size:
75 Participants
–
2014
2016
Cognitive Training protocols in people with Chronic Pain
Completed
Chronic Pain
+
Institutions:
Australia
School of Psychological Sciences, Monash University; and Caufiled Pain Management and Research Center, Caulfield Hospital
Investigators:
Melita Giummarra, Nellie Georgiou-Karistianis, Stephen Gibson, Katharine Baker
Size:
50 Participants
Publication:
Baker KS, Georgiou-Karistianis N, Lampit A, Valenzuela M, Gibson SJ, Giummarra MJ. (2018) Computerised training improves cognitive performance in chronic pain: a participant-blinded randomised active-controlled trial with remote supervision. Pain, 2018 jan. doi: 10.1097/j.pain.0000000000001150
–
2014
2016
Individualized Metacognitive Training (MCT+) Reduces Delusional Symptoms in Psychosis: A Randomized Clinical Trial
Completed
Psychosis
+
Institutions:
Australia
School of Psychology, Flinders University, Adelaide, SA
Investigators:
Ryan Balzan
Size:
70 Participants
Publication:
Balzan RP, Mattiske JK, Delfabbro P, Liu D, Galletly C. Individualized Metacognitive Training (MCT+) Reduces Delusional Symptoms in Psychosis: A Randomized Clinical Trial. Schizophr Bull. 2019;45(1):27‐36. doi:10.1093/schbul/sby152
–
2014
2015
Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning
Completed
Mental Health
Academic Success
+
Institutions:
Canada
CPLS – George Brown College – Saint James Campus – Toronto, Department of Medical Sciences – University of Western Ontario
Investigators:
Jaswant Kaur Bajwa, Alex Irwin
Size:
21 Participants
Publication:
Bajwa, J.K., Bajwa, B. and Gula, T. (2019), “Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning”, Journal of Research in Innovative Teaching & Learning, Vol. 12 No. 2, pp. 164-182.
–
2014
2017
Cognitive training to improve language comprehension for seniors?
Completed
Geriatrics
+
Institutions:
Germany
Jean-Uhrmacher Institut für klinische HNO-Forschung, Klinik und Poliklinik für Neurologie der Uniklinik Köln, Lehrstuhl für Pädagogik und Didaktik hörgeschädigter Menschen
Investigators:
Magdalene Ortmann, Harmut Meister, Josef Kessler, Thomas Kaul
Size:
50 Participants
Publication:
No Publication
–
2013
2015
Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia
Completed
Schizophrenia
Social Cognition
+
Institutions:
Canada
McGill University Psychiatry Department
Investigators:
Philippe-Olivier Harvey, Martin Lepage, Vickie Auclair
Size:
40 Participants
Publication:
No publication
–
2013
2014
Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study
Completed
Hoarding Disorder
+
Institutions:
Canada
University of British Columbia
Investigators:
Jennifer DiMauro
Size:
17 Participants
Publication:
Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.
–
2012
Conditions for Maximizing Effects of 90 Days of Brain Training
Completed
General Population
+
Institutions:
France
Scientific Brain Training
Investigators:
Franck Tarpin-Bernard, Bernard Croisile
Size:
350 Participants
Publication:
Tarpin-Bernard F, Croisile, B. Conditions for Maximizing Effects of 90 Days of Brain Training. Unpublished
–
2011
2013
Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting
Completed
SMI
+
Institutions:
Canada
Queen’s University, Kingston, ON
Investigators:
Christopher Bowie
Size:
50 Participants
Publication:
Bowie CR, Grossman M, Gupta M, Holshausen K, Best MW. Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting on functional and vocational outcomes. Psychiatr Rehabil J. 2017;40(1):53‐60. doi:10.1037/prj0000189
–
2011
Increased employability of the unemployed aged 50+ through cognitive training?
Completed
Employment
+
Institutions:
Germany
Jacobs Center on Lifelong Learning & Research Institutional Development, Jacobs University Bremen
Investigators:
B. Godde, C. M. G. Noack, C. Windisch & C. Voelcker-Rehage
Size:
87 Participants
Presentation:
Presentation
Publication:
Godde, Ben & Noack, C. Martin G. & Niemann, Claudia & Voelcker-Rehage, Claudia. (2012). Increased employability of the unemployed aged 50+ through cognitive training?. 10.13140/RG.2.1.2327.0481.
–
2010
2011
Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia
Completed
Schizophrenia
+
Institutions:
Canada
Queen’s University, Kingston, ON
Investigators:
Christopher Bowie
Size:
30 Participants
Publication:
Bowie CR, McGurk SR, Mausbach B, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real-world behavior. Am J Psychiatry. 2012;169(7):710‐718. doi:10.1176/appi.ajp.2012.11091337
–
2007
Alzheimer’s patients maintain cognitive skills and improve self confidence
Completed
Alzheimer’s Disease
+
Institutions:
France
Sophia’s Gardens, Alzheimer’s disease clinic, Castelnau-le-Lez
Investigators:
Dr. Foare
Size:
47 Participants
Presentation:
Sophia’s Gardens: AD patients maintain cognitive skills and improve self confidence
–
2007
Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans
Completed
General Population
fMRI
+
Institutions:
USA
Johnny Orr Memory Center, Iowa Health System, Funded by the Center for Disease Control
Investigators:
Robert Bender III, David Michael, Derek Campbell, Charles DePena
Presentation:
Effects of a Brain Wellness Program on Neuropsychological Testing and PET Scans
–
2006
2008
Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia.
Completed
Schizophrenia
+
Institutions:
Switzerland
Lausanne Hospital
Investigators:
Pascal Vianin
Size:
28 Participants
Publication:
Vianin, Pascal & Deppen, Patricia & Croisile, Bernard & Tarpin-Bernard, Franck & Sarrazin-Bruchez, P. & Dukes, R. & Grillon, M.L.. (2010). Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. J Cogn Rehabil. 28.
–
2006
Memory Stimulation. Which scientific benefits? Which exercises?
Completed
Geriatrics
+
Institutions:
France
Scientific Brain Training
Investigators:
Bernard Croisile et al
Size:
39 Participants
Publication:
Croile B et al.Geriatrics Review’ 2006;31:421-433 France
–
2001
2002
Transferability of Cognitive Training to every-day activities (AKA King 64)
Completed
Children
+
Institutions:
France
EMC laboratory (Université Lyon II – CNRS)
Investigators:
Michel Noir, Ph.D
Size:
117 Participants
Publication:
Thesis
–

Making Cognitive Remediation
Therapy Dynamic

Clients never get to a point where they are bored, because I have a lot of flexibility that way to keep them challenged and keep them moving.

 Debra Bushong, MS, LPC-S
HOPE program, UT Southwestern Medical Center

Read her Case Study →

Treating Brain Injuries in Colorado

HappyNeuron Pro is very elegant because it actually pinpoints cognitive areas and it gives really strong stimulus items and that’s how you actually build cognitive functions. 

Dr. Mary Ann Keatley, Ph.D., CCC,
Brain Injury Hope Foundation

Read her Case Study →

Bridging the Brain and the Classroom ​

Every kid needs to be doing HappyNeuron Pro. Every school needs to be working on these skills. Every school in America should have a cognitive skill curriculum.

Kyra Minichan, M.A., CCC-SLP
The Cognitive Emporium

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Personalizing Brain Injury Support

 HappyNeuron Pro has allowed us to have a structure so we could underpin the client’s day and start their day with it. HappyNeuron Pro allowed us to engage with clients by allowing us to look at their scores and have a conversation around that.

Natalie Mackenzie, MSc, CPCRT, CBIST
BIS Services (Brain Injury Support + Cognitive Rehabilitation)

Read her Case Study →

Making Cognitive Remediation
Therapy Dynamic

Clients never get to a point where they are bored, because I have a lot of flexibility that way to keep them challenged and keep them moving.

 Debra Bushong, MS, LPC-S
HOPE program, UT Southwestern Medical Center

Read her Case Study →

Treating Brain Injuries in Colorado

HappyNeuron Pro is very elegant because it actually pinpoints cognitive areas and it gives really strong stimulus items and that’s how you actually build cognitive functions. 

Dr. Mary Ann Keatley, Ph.D., CCC,
Brain Injury Hope Foundation

Read her Case Study →

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