Research and Clinical Studies

To support the growing body of research studying the efficacy of cognitive training, HappyNeuron Pro’s scientific team partners with research institutions worldwide to explore how HappyNeuron Pro helps with various conditions.

Below is a continually updated list of completed and ongoing studies using HappyNeuron Pro.

This page is for information only. Our goal is to help the entire digital therapeutic industry continue the research into the best way to care for individuals’ cognition. HappyNeuron does not yet sell any products or treatment tools that are FDA approved. If you are interested in using HappyNeuron in your research, please see our research offer.

2015
2016

«Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability

Completed

Intellectual disability

Children

Institutions:

France

Centre Hospitalier le Vinatier, Center of Cognitive Neuroscience, CNRS, University Lyon 1

Investigators:

Caroline Demily, Caroline Rigard, Élodie Peyroux, Gabrielle Chesnoy-Servanin, Aurore Morel, Nicolas Franck

Size:

30 Participants

Publication:

Demily, Caroline & Rigard, Caroline & Peyroux, Élodie & Chesnoy-Servanin, Gabrielle & Morel, Aurore & Franck, Nicolas. (2016). «Cognitus & Moi»: A Computer-Based Cognitive Remediation Program for Children with Intellectual Disability. Frontiers in psychiatry. 7. 10. 10.3389/fpsyt.2016.00010.

–

2014

Increased activation in Broca’s area after cognitive remediation in schizophrenia

Completed

Schizophrenia

fMRI

Institutions:

Switzerland

Lausanne Hospital

Investigators:

Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey

Size:

16 Participants

Publication:

Pascal Vianin, Sébastien Urben, Pierre Magistretti, Pierre Marquet, Eleonora Fornari, Laure Jaugey. Increased activation in Broca’s area after cognitive remediation in schizophrenia. Psychiatry Research: Neuroimaging, Volume 221. Issue 3, 30 March 2014, pp 204-209.

–

2011
2013

Cognitive Remediation for Treatment Resistant Depression

Completed

Depression

Institutions:

Canada

Queen’s University, Kingston, ON

Investigators:

Christopher Bowie

Publication:

Bowie CR, Gupta M, Holshausen K, Jokic R, Best M, Milev R. Cognitive remediation for treatment-resistant depression: effects on cognition and functioning and the role of online homework. J Nerv Ment Dis. 2013;201(8):680‐685. doi:10.1097/NMD.0b013e31829c5030

–

2008
2011

Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial

Completed

Schizophrenia

Institutions:

France

Le Vinatier Hospital – Bron, Cognitive Neuroscience Centre – Lyon, Sainte-Anne Hospital – Paris

Investigators:

Nicolas Franck

Size:

280 Participants

Publication:

Franck N, Duboc C, Sundby C, et al. Specific vs general cognitive remediation for executive functioning in schizophrenia: a multicenter randomized trial. Schizophr Res. 2013;147(1):68‐74. doi:10.1016/j.schres.2013.03.009

–

2020
2024

Efficacy of Personalizing Cognitive Remediation for Schizophrenia by Targeting Impairments in Early Auditory Processing

In Progress

Schizophrenia

Institutions:

USA

Columbia University, NIMH

Investigators:

Alice Medalia, Alice Saperstein, Daniel Javitt, Min Qian

Size:

200 Participants

Trial Registration:

See Registration

–

2020
2021

A Measure of the Efficacy of Cognitive Remediation Therapy in an Inpatient Setting

In Progress

Schizophrenia

Bipolar

Institutions:

Canada

Saskatchewan Health Authority

Investigators:

Brent Nixon, Anne Pleydon, Christine Tait, Kingsley Nwachukwu, Fiyinfoluwa Peluola, Mansfield Mela

Size:

48 Participants

–

2020
2022

Cognitive Remediation in Forensic Mental Health Care

In Progress

Forensics

Mental Heath

Institutions:

Canada

The Royal Ottawa Mental Health Centre

Investigators:

Patrizia Pezzoli, Michael Seto, Synthia Guimond, Sanjiv Gulati

Size:

30 Participants

Trial Registration:

See Registration

Presentation:

Abstract at the Cognitive Remediation Conference 2022

–

2019
2021

A randomised controlled trial of psychotherapy and cognitive remediation to target cognition in mood disorders

Completed

Bipolar

Mood

Institutions:

New Zealand

University of Otago, Christchurch

Investigators:

Katie M. Douglas,Samantha Groves,Marie T. Crowe,Maree L. Inder,Jennifer Jordan,Dave Carlyle,Hayley Wells,Ben Beaglehole,Roger Mulder,Cameron Lacey,Suzanne E. Luty,Kate Eggleston,Christopher M. A. Frampton,Christopher R. Bowie,Richard J. Porter

Size:

68 Participants

Publication:

Douglas, KM, Groves, S, Crowe, MT, et al. A randomised controlled trial of psychotherapy and cognitive remediation to target cognition in mood disorders. Acta Psychiatr Scand. 2022; 145: 278– 292. doi:10.1111/acps.13387

–

2018
2019

An Evaluation of the Effectiveness and Feasibility of a Cognitive Remediation Program in a Residential Substance Use Treatment Facility

In Progress

Addiction

Institutions:

Australia

Wattlegrove Rehab Program, University of Queensland, Lives lived well

Investigators:

Leanne Hides, Julaine Allan, Anna Thompson, Frances Dark

Size:

65 Participants

Presentation:

Poster presented in Nov 2019 at the Australasian Professional Society for Alcohol and other Drugs

Publication:

Pending

–

2018
2021

Examine the effects of prolonged cognitive remediation on sustaining cognitive gains and functional recovery in schizophrenia.

In Progress

Schizophrenia

Institutions:

Singapore

Institute of Mental Health, Singapore Institute of Technology

Investigators:

Ho New Fei, Sim Kang Jimmy, Chee Keong Lee, Chen Guoyang, Wang Mingyuan, Suhailah Bte Abd Shukor, Daniel Poremski

Size:

45 Participants

–

2017
2019

Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.

Completed

Bipolar

Institutions:

Denmark

Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet

Investigators:

Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW

Size:

58 Participants

Trial Registration:

See Registration

Publication:

Ott CV, Vinberg M, Bowie CR, et al. Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial [published correction appears in Trials. 2019 Apr 8;20(1):201]. Trials. 2018;19(1):487. Published 2018 Sep 12. doi:10.1186/s13063-018-2860-8

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2016
2017

Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial

Completed

SMI

Employment

Institutions:

Australia

University of Sydney, Macquarie University

Investigators:

Anthony WF Harris, Tanya Kosic, Jean Xu, Chris Walker, William Gye, Antoinette Redoblado Hodge

Size:

86 Participants

Trial Registration:

See Registration

Publication:

Harris AW, Kosic T, Xu J, Walker C, Gye W, Redoblado Hodge A. Web-Based Cognitive Remediation Improves Supported Employment Outcomes in Severe Mental Illness: Randomized Controlled Trial. JMIR Ment Health. 2017;4(3):e30. Published 2017 Sep 20. doi:10.2196/mental.6982

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2015
2020

The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial

Completed

Psychosis

Institutions:

Denmark

Psychiatric Center Copenhagen

Investigators:

Louise B Glenthøj, Birgitte Fagerlund, Lasse Randers, Carsten R Hjorthøj, Christina Wenneberg, Kristine Krakauer, Astrid Vosgerau, Christian Gluud, Alice Medalia, David L Roberts, Merete Nordentoft

Size:

126 Participants

Trial Registration:

See Registration

Publication:

Glenthøj LB, Fagerlund B, Randers L, et al. The FOCUS trial: cognitive remediation plus standard treatment versus standard treatment for patients at ultra-high risk for psychosis: study protocol for a randomised controlled trial. Trials. 2015;16:25. Published 2015 Jan 27. doi:10.1186/s13063-014-0542-8

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2014
2019

Effectiveness of metacognitive training (MCT) and cognitive remediation (CR) at treating the persistent symptoms and functional deficits present in those with schizophrenia

In Progress

Schizophrenia

Institutions:

Canada

University of British Columbia

Investigators:

Todd Woodward

Size:

75 Participants

–

2014
2015

Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning

Completed

Mental Health

Academic Success

Institutions:

Canada

CPLS – George Brown College – Saint James Campus – Toronto, Department of Medical Sciences – University of Western Ontario

Investigators:

Jaswant Kaur Bajwa, Alex Irwin

Size:

21 Participants

Publication:

Bajwa, J.K., Bajwa, B. and Gula, T. (2019), “Facilitating success for people with mental health issues in a college through cognitive remediation therapy and social and emotional learning”, Journal of Research in Innovative Teaching & Learning, Vol. 12 No. 2, pp. 164-182.

–

2013
2015

Effects and efficacy of specialized social cognitive therapy compared to cognitive remediation therapy in people with schizophrenia

Completed

Schizophrenia

Social Cognition

Institutions:

Canada

McGill University Psychiatry Department

Investigators:

Philippe-Olivier Harvey, Martin Lepage, Vickie Auclair

Size:

40 Participants

Publication:

No publication

–

2013
2014

Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study

Completed

Hoarding Disorder

Institutions:

Canada

University of British Columbia

Investigators:

Jennifer DiMauro

Size:

17 Participants

Publication:

Jennifer DiMauro, Marla Genova, David F. Tolin, Matthew M. Kurtz, Cognitive remediation for neuropsychological impairment in hoarding disorder: A pilot study, Journal of Obsessive-Compulsive and Related Disorders, Available online 2 April 2014, ISSN 2211-3649.

–

2011
2013

Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting

Completed

SMI

Institutions:

Canada

Queen’s University, Kingston, ON

Investigators:

Christopher Bowie

Size:

50 Participants

Publication:

Bowie CR, Grossman M, Gupta M, Holshausen K, Best MW. Action-based cognitive remediation for individuals with serious mental illnesses: Effects of real-world simulations and goal setting on functional and vocational outcomes. Psychiatr Rehabil J. 2017;40(1):53‐60. doi:10.1037/prj0000189

–

2010
2011

Cognitive Remediation Early Episode vs. Chronic Outpatients with Schizophrenia

Completed

Schizophrenia

Institutions:

Canada

Queen’s University, Kingston, ON

Investigators:

Christopher Bowie

Size:

30 Participants

Publication:

Bowie CR, McGurk SR, Mausbach B, Patterson TL, Harvey PD. Combined cognitive remediation and functional skills training for schizophrenia: effects on cognition, functional competence, and real-world behavior. Am J Psychiatry. 2012;169(7):710‐718. doi:10.1176/appi.ajp.2012.11091337

–

2006
2008

Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia.

Completed

Schizophrenia

Institutions:

Switzerland

Lausanne Hospital

Investigators:

Pascal Vianin

Size:

28 Participants

Publication:

Vianin, Pascal & Deppen, Patricia & Croisile, Bernard & Tarpin-Bernard, Franck & Sarrazin-Bruchez, P. & Dukes, R. & Grillon, M.L.. (2010). Exploratory Investigation of a Customized cognitive remediation program for individuals living with schizophrenia. J Cogn Rehabil. 28.

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Treating Brain Injuries in Colorado

HappyNeuron Pro is very elegant because it actually pinpoints cognitive areas and it gives really strong stimulus items and that’s how you actually build cognitive functions.

Dr. Mary Ann Keatley, Ph.D., CCC,
Brain Injury Hope Foundation

Bridging the Brain and the Classroom

Every kid needs to be doing HappyNeuron Pro. Every school needs to be working on these skills. Every school in America should have a cognitive skill curriculum.

Kyra Minichan, M.A., CCC-SLP
The Cognitive Emporium

Personalizing Brain Injury Support

HappyNeuron Pro has allowed us to have a structure so we could underpin the client’s day and start their day with it. HappyNeuron Pro allowed us to engage with clients by allowing us to look at their scores and have a conversation around that.

Natalie Mackenzie, MSc, CPCRT, CBIST
BIS Services (Brain Injury Support + Cognitive Rehabilitation)

Making Cognitive Remediation
Therapy Dynamic

Clients never get to a point where they are bored, because I have a lot of flexibility that way to keep them challenged and keep them moving.

Debra Bushong, MS, LPC-S
HOPE program, UT Southwestern Medical Center

Overview

Tools

Types of Cognitive Exercises

Practioners

Therapy

Treatment Guidelines

Book a meeting to learn about:

Free Resources

Featured Content

Research and Clinical Studies

Treating Brain Injuries in Colorado

Bridging the Brain and the Classroom

Personalizing Brain Injury Support

Making Cognitive Remediation
Therapy Dynamic

Learn how you can integrate HappyNeuron Pro into your research

Overview

Tools

Types of Cognitive Exercises

Practioners

Therapy

Treatment Guidelines

Book a meeting to learn about:

Free Resources

Featured Content

Research and Clinical Studies

Treating Brain Injuries in Colorado

Bridging the Brain and the Classroom ​

Personalizing Brain Injury Support

Making Cognitive Remediation Therapy Dynamic

Learn how you can integrate HappyNeuron Pro into your research

Bridging the Brain and the Classroom

Making Cognitive Remediation
Therapy Dynamic